Threonine 188 is critical for interaction with NAD+ in research subjects [PMID: 10198228] Laboratory literature summary: Threonine 188 is critical for interaction with NAD+ in research subjects NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
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Dose and timing should follow a confirmed deficiency and your GPs review, not a fixed course sold in advance
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MOTS-c is generally dosed once daily in the morning